What are the Challenges of Using BET Inhibitors in Pediatrics?
The use of BET inhibitors in pediatric patients poses several challenges: - Safety and Tolerability: Children's metabolic and developmental stages differ significantly from adults, necessitating thorough evaluation of the safety profiles. - Dosage: Determining the appropriate dosage for pediatric patients is complex and requires careful consideration of pharmacokinetics and pharmacodynamics. - Resistance: As with many targeted therapies, there is a risk of developing resistance, which could limit the long-term efficacy of BET inhibitors.
