What are the challenges of conducting EWAS in Pediatrics?
Conducting EWAS in pediatric populations presents several challenges:
1. Sample Collection: Obtaining sufficient and high-quality DNA samples from children can be difficult. Non-invasive methods like collecting buccal swabs or cord blood are often preferred.
2. Timing of Sampling: The epigenome is highly dynamic, especially during early childhood. The timing of sample collection can significantly impact the findings, necessitating careful planning and longitudinal studies.
3. Interpretation of Results: Differentiating between causal and correlational epigenetic changes is complex. Not all identified epigenetic marks are functionally relevant, making it essential to validate findings through additional functional studies.
