Several gene-drug pairs are particularly relevant in pediatrics. Some examples include:
- CYP2D6 and codeine: Variants in the CYP2D6 gene can affect how children metabolize codeine, impacting its efficacy and risk of adverse effects. - TPMT and thiopurines: TPMT enzyme activity affects the metabolism of thiopurines, which are used to treat pediatric leukemias and autoimmune conditions. - SLCO1B1 and statins: Variants in SLCO1B1 can influence the risk of muscle toxicity in children prescribed statins for familial hypercholesterolemia.
