What Are the Challenges in TDM for Pediatric Patients?
- Sample Volume: Infants and young children have limited blood volume, making frequent sampling challenging. - Pharmacokinetic Variability: Rapid growth and development can cause significant changes in drug metabolism and excretion. - Compliance: Ensuring adherence to medication schedules can be difficult in pediatric patients, complicating TDM. - Limited Data: There is often less pharmacokinetic and pharmacodynamic data available for children compared to adults.
