What Are Some Key Neonatal Disorders Linked to DNA Methylation?
Some key neonatal disorders associated with abnormal DNA methylation include:
Prader-Willi Syndrome: Caused by a lack of expression of paternal genes in the 15q11-q13 region, often due to methylation abnormalities. Angelman Syndrome: Results from the loss of maternal gene expression in the same chromosomal region. Silver-Russell Syndrome: Characterized by growth retardation, often linked to hypomethylation of the H19/IGF2 locus. Rett Syndrome: Caused by mutations in the MECP2 gene, which is involved in methyl-CpG binding and gene regulation.
