What Are Some Common Neuroprotective Agents Used in Neonates?
Several neuroprotective agents have been studied for their efficacy in neonatal disorders:
1. Magnesium Sulfate: Often used in preterm labor, magnesium sulfate has shown promise in reducing the risk of cerebral palsy in preterm infants. 2. Therapeutic Hypothermia: Cooling the infant's body to 33.5-34.5 degrees Celsius can significantly reduce brain injury following hypoxic-ischemic encephalopathy. 3. Erythropoietin: This hormone, primarily known for its role in red blood cell production, has neuroprotective properties that can help mitigate brain injury. 4. Melatonin: Known for its antioxidant properties, melatonin can help reduce oxidative stress and inflammation in the neonatal brain. 5. Allopurinol: This drug, typically used for gout, has shown potential in reducing oxidative damage when administered shortly after a hypoxic-ischemic event.
