How is Drug Excretion Handled in Pediatric Patients?
Renal function, responsible for drug excretion, also matures over time. Neonates have immature kidneys with reduced glomerular filtration rate (GFR), tubular secretion, and reabsorption. This can lead to prolonged drug half-lives and increased risk of accumulation and toxicity. As renal function matures, usually within the first year of life, drug clearance improves, and dosing adjustments may be necessary.
