Diagnosis of ALL typically involves several steps:
Physical examination to check for signs of disease such as swollen lymph nodes, liver, or spleen. Blood tests, including a complete blood count (CBC), to detect abnormalities in white blood cell, red blood cell, and platelet counts. Bone marrow biopsy where a sample of bone marrow is taken to look for leukemia cells. Imaging tests such as X-rays, CT scans, or ultrasounds to check for spread to other organs. Genetic testing to identify specific chromosomal abnormalities that may influence treatment options.