How Does GDNF Affect Pediatric Neurological Development?
GDNF acts by binding to its receptor complex, which includes the GDNF family receptor alpha (GFRα) and the Ret tyrosine kinase receptor. This binding triggers intracellular signaling pathways that promote neuron survival and differentiation. In children, adequate levels of GDNF are necessary for the proper development of the central and peripheral nervous systems. Insufficient or excessive levels of GDNF can lead to developmental issues and neurological disorders.
