Antisense oligonucleotides are synthesized to be complementary to the mRNA of a target gene. When these ASOs bind to their target mRNA, they can prevent the mRNA from being translated into a protein. This can be particularly useful in the context of genetic mutations that lead to overproduction or aberrant production of harmful proteins. By halting the production of these proteins, antisense technology can mitigate or even prevent the development of disease symptoms.