How do Transcription Factors Influence Pediatric Diseases?
Several pediatric diseases are linked to mutations or dysregulations in transcription factors. For example, mutations in the GATA1 transcription factor can lead to blood disorders like congenital dyserythropoietic anemia. Similarly, the PAX6 gene, which is crucial for eye development, can result in aniridia when mutated. Understanding these links helps in diagnosing and developing targeted therapies for such conditions.
