Interleukins can have both protective and pathological effects in pediatric diseases. For instance, Interleukin-1 (IL-1) and Interleukin-6 (IL-6) are key mediators of inflammation and are often elevated in conditions such as juvenile idiopathic arthritis and Kawasaki disease. On the other hand, Interleukin-10 (IL-10) has anti-inflammatory properties and can help mitigate excessive immune responses.