Researchers can adopt several strategies to address these challenges:
Multicenter Trials: Collaborating with multiple centers can help increase sample sizes and generalizability of results. Age-Appropriate Measures: Using validated, age-appropriate instruments to assess outcomes ensures relevance and accuracy. Parental Involvement: Engaging parents and guardians in the research process can enhance recruitment and ethical conduct. Transparency: Adhering closely to CONSORT guidelines and providing detailed trial protocols and statistical analysis plans improves transparency and reproducibility.
