The safety of DMARDs during pregnancy varies depending on the specific drug. For example:
- Methotrexate is contraindicated during pregnancy due to its teratogenic effects. - Hydroxychloroquine is generally considered safe and is often used to manage lupus during pregnancy. - Sulfasalazine can be used, but it is often supplemented with folic acid to prevent deficiencies. - Biologic DMARDs like TNF inhibitors have a variable safety profile, and the decision to continue them often depends on the balance between disease control and potential risks to the fetus.
Pregnant women on DMARDs should be closely monitored by a multidisciplinary team to ensure the optimal outcome for both mother and baby.
