What are Bone Sarcomas?
Bone sarcomas are a group of malignant tumors that originate in the bone. They are relatively rare but are among the most common types of primary bone cancers in children and adolescents. The two most common types are
osteosarcoma and
Ewing sarcoma.
Who is at Risk?
Bone sarcomas primarily affect children and teenagers, typically during periods of rapid growth such as adolescence. Boys are more commonly affected than girls. Certain genetic conditions like
Li-Fraumeni syndrome and familial retinoblastoma increase the risk of developing bone sarcomas.
Pain in the affected bone, which may worsen at night or with activity
Swelling and tenderness near the affected area
Decreased mobility in the affected limb
Unexplained
fractures due to weakened bone
X-rays to identify abnormalities in bone structure
MRI (Magnetic Resonance Imaging) to assess the local extent of the tumor
CT scans (Computed Tomography) to check for metastasis
Biopsy to confirm the diagnosis and determine the specific type of sarcoma
The choice of treatment depends on the type, location, and stage of the sarcoma, as well as the patient's overall health.
What is the Prognosis?
The prognosis for children with bone sarcomas has improved significantly with advances in treatment. Factors that influence prognosis include:
The type and stage of the sarcoma
The location and size of the tumor
How much of the tumor can be surgically removed
Response to chemotherapy
Generally, the 5-year survival rate for localized osteosarcoma is around 70%, while for Ewing sarcoma, it is about 70-80% if the cancer has not spread.
Providing
psychosocial support through counseling and support groups
Offering financial aid and resources to help with treatment costs
Ensuring clear communication between healthcare providers and families
Coordinating with educational institutions to support the child’s learning needs
Future Directions
Research is ongoing to improve the understanding and treatment of pediatric bone sarcomas. Current areas of focus include: Developing
targeted therapies that specifically attack cancer cells
Exploring the role of
immunotherapy in treating bone sarcomas
Improving surgical techniques to preserve more of the affected limb