Why Do Males Predominate in X-Linked Recessive Disorders?
Males are more frequently affected by X-linked recessive disorders due to their single X chromosome. If a male inherits an X chromosome carrying a recessive mutation, there is no second X chromosome to mask the effect of the mutation. Consequently, the disorder manifests in males. Females, with two X chromosomes, are less likely to be affected because the normal gene on the second X chromosome can often compensate for the defective gene.
