Subtherapeutic dosing in children can occur for several reasons:
Incorrect Dosage Calculation: Pediatric dosages are typically calculated based on weight or body surface area. Errors in these calculations can lead to subtherapeutic levels. Non-adherence: Children may refuse to take their medication, or parents may forget to administer it, leading to inconsistent dosing. Incomplete Absorption: Medications may not be fully absorbed due to gastrointestinal issues, which are more common in children. Drug Interactions: Other medications or food can interact and decrease the efficacy of a given drug.
