Neonates are at an increased risk for ADRs due to several factors:
Immature liver and kidney function: These organs are crucial for drug metabolism and excretion. In neonates, their immaturity can lead to drug accumulation and toxicity. Skin permeability: Neonates, especially preterm infants, have more permeable skin, which can increase the risk of systemic toxicity from topically applied medications. Blood-Brain Barrier: The blood-brain barrier is not fully developed, making neonates more vulnerable to central nervous system side effects. Body composition: Higher water content and lower fat proportion can affect the distribution of water-soluble and fat-soluble drugs.
