Acyclovir is indicated for use in neonates diagnosed with or suspected of having HSV infection. This can include:
Neonates presenting with symptoms of HSV infection such as vesicular lesions on the skin, eyes, or mouth. Neonates with confirmed HSV infection through laboratory tests such as PCR (Polymerase Chain Reaction). Neonates born to mothers with active genital herpes at the time of delivery. Neonates showing signs of systemic illness where HSV infection is a differential diagnosis.