dosing

What Role Does Pharmacokinetics Play in Pediatric Dosing?

Pharmacokinetics involves how a drug is absorbed, distributed, metabolized, and excreted in the body. In children, these processes can vary widely:
- Absorption: Gastric pH, gastric emptying time, and enzyme activity can affect drug absorption.
- Distribution: Body water and fat composition change with age, affecting how drugs distribute in the body.
- Metabolism: Liver enzyme activity increases with age.
- Excretion: Kidney function matures over time, influencing drug clearance.

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