What Pathophysiological Mechanisms Are Involved in TRALI?
TRALI is thought to be caused by two main mechanisms: 1. Immune-mediated: The presence of anti-leukocyte antibodies in the donor blood that react with recipient leukocytes. 2. Non-immune mediated: The accumulation of bioactive lipids and other mediators during storage of blood products which can induce neutrophil activation upon transfusion.