Several neonatal disorders are associated with abnormal ACTH levels:
Congenital Adrenal Hyperplasia (CAH): This genetic disorder affects cortisol synthesis. Elevated ACTH levels are often observed as the pituitary gland tries to stimulate the adrenal cortex to produce more cortisol. Neonatal Adrenal Insufficiency: This condition can result from various factors, including premature birth or maternal steroid use. Low ACTH levels can indicate a failure of the hypothalamic-pituitary-adrenal (HPA) axis. Sepsis: Infections can disrupt the HPA axis, often leading to altered ACTH and cortisol levels. Monitoring these levels can be crucial for managing septic neonates.
