Group sequential design (GSD) is a statistical method employed in clinical trials that allows for interim analyses of the data at various points throughout the study. This approach can be particularly beneficial in the context of neonatal disorders, where timely decisions are critical for the health and survival of newborns. GSD enables researchers to stop a trial early for efficacy, futility, or safety reasons, thereby potentially reducing the duration of the trial and the number of participants exposed to potentially harmful or ineffective treatments.
