Several factors influence pediatric dosing, including:
1. Age: Different age groups (neonates, infants, toddlers, school-aged children, and adolescents) metabolize drugs differently. 2. Weight: Doses are often calculated on a per-kilogram basis. 3. Body Surface Area (BSA): Some medications are dosed based on BSA to account for the child’s growth. 4. Organ Maturity: Liver and kidney functions impact drug metabolism and excretion. 5. Pharmacokinetics and Pharmacodynamics: The way a drug is absorbed, distributed, metabolized, and excreted differs in children.
