Age: Different age groups metabolize drugs differently. Neonates, infants, children, and adolescents each have unique pharmacokinetic profiles. Weight: Heavier children often require higher doses to achieve the same drug concentration as lighter children. Organ Function: Kidney and liver function are critical in drug metabolism and excretion. Impaired function necessitates dose adjustment. Genetic Factors: Genetic polymorphisms can affect drug metabolism, making pharmacogenetic testing useful in some cases. Disease State: Certain diseases can alter drug pharmacokinetics, requiring dose modifications.
