What Challenges Exist in Enzyme Engineering for Neonatal Disorders?
Despite its potential, enzyme engineering faces several challenges. One major issue is the immune response to engineered enzymes. The body's immune system may recognize these enzymes as foreign and mount an attack, reducing their efficacy. Another challenge is ensuring the stability and activity of the engineered enzymes in the human body, where conditions such as pH and temperature can vary. Additionally, delivering these enzymes to the appropriate tissues and cells remains a significant hurdle.
