The causes of neonatal adrenal insufficiency can be broadly categorized into primary and secondary:
1. Primary adrenal insufficiency: This occurs due to intrinsic problems with the adrenal glands themselves, such as congenital adrenal hyperplasia (CAH), adrenal hemorrhage, or genetic disorders like adrenal hypoplasia congenita. 2. Secondary adrenal insufficiency: This arises from a problem with the pituitary gland or hypothalamus, leading to inadequate production of adrenocorticotropic hormone (ACTH), which stimulates the adrenal glands.
