Over-the-counter medications like antihistamines (e.g., dimenhydrinate) can be used to treat motion sickness in children. However, it's important to consult a healthcare provider before administering any medication. For children over 12, bismuth subsalicylate (e.g., Pepto-Bismol) may be an option, but it is not recommended for younger children due to the risk of Reye's syndrome.