Coloboma: A defect in the eye that can affect the iris, retina, or optic nerve. Heart Defects: Congenital heart defects are common and can include atrial septal defect, ventricular septal defect, and tetralogy of Fallot. Atresia Choanae: A blockage of the nasal passage that can cause breathing difficulties. Retarded Growth and Development: Delays in physical growth and motor skills are often observed. Genital Abnormalities: These can include micropenis, cryptorchidism, and hypogonadism in males, and hypoplastic labia in females. Ear Abnormalities: These can include malformed outer ears, hearing loss, and balance issues due to inner ear abnormalities.