Several factors must be considered before initiating immunoglobulin therapy in neonates: - Clinical Indication: Clear diagnosis and evidence supporting the use of immunoglobulins. - Dosage and Administration: Tailored to the neonate’s specific needs and monitored closely. - Monitoring for Adverse Effects: Regular monitoring for potential side effects and complications. - Cost and Availability: Immunoglobulin therapy can be expensive and may not be readily available in all settings.