Children with Trisomy 13 often exhibit a range of clinical features, including:
- Craniofacial abnormalities: These can include microcephaly, cleft lip and/or palate, and microphthalmia. - Central nervous system anomalies: Such as holoprosencephaly, a condition where the brain does not divide properly into two hemispheres. - Cardiac defects: Congenital heart defects are common, including ventricular septal defect (VSD) and atrial septal defect (ASD). - Polydactyly: Extra fingers or toes. - Growth retardation: Both intrauterine and postnatal growth can be significantly affected. - Urogenital anomalies: Kidney malformations and abnormal genitalia.
