Conducting clinical trials in children presents unique challenges:
Ethical Concerns: Obtaining informed consent from parents or guardians, and assent from older children, can be complex. Recruitment: Enrolling a sufficient number of pediatric participants is often difficult. Dosing: Determining the correct dosage for different age groups requires extensive pharmacokinetic and pharmacodynamic studies. Safety: Children may have different adverse reactions compared to adults, necessitating close monitoring.
