The combination of dihydroartemisinin and piperaquine offers several benefits: - High Efficacy: It has a high cure rate for uncomplicated Plasmodium falciparum malaria. - Long Half-life: Piperaquine has a long half-life, providing a prolonged protective effect against reinfection. - Convenience: The once-daily dosing over three days improves adherence to the treatment regimen. - Safety: Clinical trials have shown that DHA-PPQ is well-tolerated in children, with mild and transient side effects.