What are the administration guidelines for Nusinersen?
Nusinersen is initially administered in four loading doses. The first three doses are given at 14-day intervals, and the fourth dose is administered 30 days after the third dose. Following the loading doses, maintenance doses are given every four months. The intrathecal injection is typically performed by a healthcare professional experienced in lumbar punctures, often under sedation or anesthesia in very young infants.
