Several neonatal disorders have a genetic basis. Some of the most common include: - Down Syndrome: Caused by an extra copy of chromosome 21, leading to intellectual disability and various health issues. - Spina Bifida: A neural tube defect linked to genetic and environmental factors. - Phenylketonuria (PKU): A metabolic disorder due to mutations in the PAH gene, resulting in the inability to metabolize the amino acid phenylalanine.