- Dose Adjustment: Careful calculation of the drug dosage based on the child's weight and renal function can reduce the risk of nephrotoxicity. - Hydration: Ensuring adequate hydration can help in flushing out the nephrotoxic substances from the kidneys. - Monitoring: Regular monitoring of kidney function through blood tests and urine analysis can help detect early signs of nephrotoxicity. - Alternative Medications: Whenever possible, opt for medications with a lower nephrotoxic profile.