Diagnosis of NMG is largely clinical, based on the neonate's symptoms and the mother’s history of myasthenia gravis. Specific tests can also support the diagnosis:
- Tensilon test: An injection of edrophonium chloride may temporarily improve muscle strength. - Electromyography (EMG): Can show a pattern of muscle weakness typical of MG. - Blood tests: Detect the presence of maternal antibodies against acetylcholine receptors in the infant’s blood.