Artesunate can be administered in several forms, including oral, rectal, and intravenous (IV). However, in cases of severe malaria, the IV form is preferred to ensure rapid action. The dosage and administration depend on the child's weight and the severity of the infection. The typical regimen involves an initial dose followed by subsequent doses at 12 and 24 hours, and then daily until the child can be switched to an oral antimalarial to complete the treatment course.