Elexacaftor is a CFTR corrector. It helps the CFTR protein fold correctly, increasing the amount of functional protein that reaches the cell surface. This action is particularly beneficial for patients with the F508del mutation, the most common mutation in cystic fibrosis. When used in combination with tezacaftor and ivacaftor, elexacaftor enhances chloride transport across cell membranes, which helps to thin mucus and reduce inflammation.
