Modifier genes can have a profound impact on the clinical outcomes of neonates with genetic disorders. For instance, in conditions like cystic fibrosis, different modifier genes can influence lung function, nutritional status, and infection rates, resulting in diverse clinical manifestations. In congenital heart diseases, modifier genes can determine the severity of the malformation and the success of surgical interventions. Essentially, these genes add another layer of complexity to the already intricate genetic landscape of neonatal disorders.