Vaccination is the most effective way to prevent Diphtheria, Tetanus, and Pertussis. The DTaP vaccine is administered to children at 2, 4, 6, and 15-18 months, with a booster at 4-6 years. For older children and adults, the Tdap vaccine is recommended as a booster. It's essential for pregnant women to receive the Tdap vaccine to protect newborns.