In neonatal medicine, NSAIDs are primarily used for the management of specific conditions such as Patent Ductus Arteriosus (PDA). PDA is a condition where the ductus arteriosus, a blood vessel in the heart, fails to close after birth, leading to abnormal blood flow between the aorta and the pulmonary artery. NSAIDs like Ibuprofen and Indomethacin are used to encourage the closure of this vessel.