Preventing immune dysregulation in neonates can be challenging, especially in cases of genetic predisposition. However, certain measures can reduce the risk, such as ensuring timely prenatal care to manage maternal infections and conditions, administering vaccinations like the flu shot to pregnant women, and maintaining a sterile environment in neonatal intensive care units (NICUs). Breastfeeding can also provide essential antibodies that help bolster the neonate's immune system.