Persistent Fever - Neonatal Disorders

What is Persistent Fever in Pediatrics?

Persistent fever in children is defined as a fever lasting more than 7-10 days. It is a common concern in pediatric practice and can be challenging to diagnose due to the wide array of potential causes. Fever is generally considered a body temperature above 38°C (100.4°F).

Common Causes of Persistent Fever

There are numerous potential causes of persistent fever in children. Some of the most common include:
Viral infections like Epstein-Barr virus (EBV) or cytomegalovirus (CMV).
Bacterial infections such as urinary tract infections (UTIs), pneumonia, or sinusitis.
Autoimmune diseases like juvenile idiopathic arthritis (JIA).
Malignancies such as leukemia or lymphoma.
Miscellaneous causes like drug fever or Kawasaki disease.

When to Seek Medical Attention?

Parents should seek medical attention if their child has a fever lasting more than 3 days, especially if it is accompanied by other symptoms such as:
Difficulty breathing
Persistent vomiting or diarrhea
Severe headache or stiff neck
Rash
Unusual drowsiness or irritability
Dehydration

Diagnostic Approach

The diagnostic approach to persistent fever involves a thorough history and physical examination. Important aspects include:
Detailed history of the fever's pattern and associated symptoms.
Review of the child's medical history and any recent exposures or travel.
Physical examination focusing on signs of infection, inflammation, or organ dysfunction.

Investigations

Depending on the initial assessment, various investigations may be warranted, including:
Blood tests (e.g., complete blood count, inflammatory markers).
Urinalysis and urine culture.
Chest X-ray or other imaging studies.
Specialized tests like autoimmune panels or bone marrow biopsy in certain cases.

Treatment

Treatment of persistent fever depends on the underlying cause. General measures include:
Ensuring adequate hydration and rest.
Use of antipyretics like acetaminophen or ibuprofen to reduce fever and discomfort.
Specific treatments may involve:
Antibiotics for bacterial infections.
Antivirals for certain viral infections.
Anti-inflammatory or immunosuppressive medications for autoimmune diseases.

Prognosis

The prognosis for children with persistent fever varies depending on the underlying cause. Many cases resolve with appropriate treatment, but some conditions may require long-term management. Early diagnosis and intervention are crucial for improving outcomes.

Prevention

Preventive measures include:
Ensuring up-to-date vaccinations.
Maintaining good hygiene practices to reduce infection risk.
Regular medical check-ups to monitor health and catch potential issues early.

Conclusion

Persistent fever in children is a significant concern that warrants a thorough evaluation to determine the underlying cause. With appropriate diagnosis and treatment, most children can recover fully. Parents and caregivers should be vigilant and seek medical advice if a child's fever persists or is accompanied by concerning symptoms.

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