Mycobacterium tuberculosis - Neonatal Disorders

What is Mycobacterium Tuberculosis?

Mycobacterium tuberculosis is a bacterium that causes tuberculosis (TB), a potentially serious infectious disease. While adults are more commonly affected, children can also contract TB, often through close contact with an infected adult.

How is TB Transmitted in Children?

TB is primarily spread through the air when an infected person coughs, sneezes, or talks, releasing aerosolized droplets containing the bacteria. Children are usually infected by a family member or someone in their close environment. Young children are particularly susceptible due to their weaker immune systems.

What are the Symptoms of TB in Children?

Symptoms of TB in children can be non-specific and may include:
Persistent cough
Fever
Weight loss or failure to thrive
Night sweats
Fatigue and irritability
Swollen lymph nodes

How is TB Diagnosed in Children?

Diagnosing TB in children can be challenging due to the non-specific symptoms. Diagnostic methods include:
Tuberculin Skin Test (TST) – This test involves injecting a small amount of tuberculin into the skin and checking for a reaction 48-72 hours later.
Interferon-Gamma Release Assays (IGRAs) – Blood tests that measure the immune response to TB bacteria.
Chest X-ray – Used to look for signs of TB in the lungs.
Sputum Culture – Collecting and analyzing sputum samples for the presence of TB bacteria, although this is less commonly done in young children who may not produce sputum.

What is the Treatment for TB in Children?

Treatment for TB involves a combination of antibiotics over an extended period, typically 6 months or longer. The first-line drugs include:
It is crucial to adhere to the prescribed treatment regimen to prevent the development of drug-resistant TB.

Can TB Be Prevented in Children?

Prevention strategies include:
BCG Vaccine – This vaccine provides some protection against TB, especially severe forms in children, and is often given in countries with high TB prevalence.
Screening and treating close contacts of TB patients to prevent the spread of the infection.
Improving living conditions to reduce overcrowding and enhance ventilation.

What are the Complications of TB in Children?

Untreated or inadequately treated TB can lead to severe complications, such as:
Miliary TB – Disseminated TB that spreads throughout the body.
Tuberculous Meningitis – Infection of the membranes covering the brain and spinal cord, which can be life-threatening.
Permanent lung damage or other organ damage.

What is the Prognosis for Children with TB?

With early diagnosis and appropriate treatment, the prognosis for children with TB is generally good. However, delays in treatment or non-compliance with the treatment regimen can lead to more severe disease and complications.



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