What is MODY?
Maturity Onset Diabetes of the Young (MODY) is a monogenic form of diabetes, meaning it is caused by a mutation in a single gene. Unlike the more common types of diabetes such as Type 1 and Type 2, MODY is inherited in an autosomal dominant manner. This implies that a child has a 50% chance of inheriting the condition if one parent is affected.
It typically presents before the age of 25.
Unlike Type 1 diabetes, patients do not typically require insulin treatment immediately.
The condition is
non-ketotic, meaning it usually does not cause diabetic ketoacidosis.
Patients often have a strong family history of diabetes.
What are the types of MODY?
There are several subtypes of MODY, each associated with different gene mutations. The most common types include:
A detailed family history of diabetes.
Clinical features such as age of onset and absence of obesity or insulin resistance.
Genetic testing to identify specific gene mutations.
MODY 2 often requires no medication and is managed with lifestyle changes.
MODY 1 and
MODY 3 may respond well to oral sulfonylureas, rather than insulin.
Regular monitoring of blood glucose levels is essential.
What is the prognosis for children with MODY?
The prognosis for children with MODY is generally favorable if the condition is correctly diagnosed and managed. Unlike Type 1 diabetes, MODY generally has a less aggressive course and fewer complications when treated appropriately.
Prevent misdiagnosis and inappropriate treatment strategies.
Help in selecting the most effective medication, avoiding unnecessary insulin administration.
Provide genetic counseling for the family, as MODY is hereditary.
Family history is crucial. If there is a history of diabetes diagnosed at a young age in the family, genetic testing might be necessary.
Children with MODY generally do not exhibit the same risk factors as Type 2 diabetes, such as obesity.
Lifestyle management, including a balanced diet and regular exercise, plays a significant role in managing the condition.
