Celiac Disease - Neonatal Disorders

What is Celiac Disease?

Celiac disease is an autoimmune disorder that affects the small intestine when gluten, a protein found in wheat, barley, and rye, is ingested. In children, this condition can interfere with nutrient absorption and lead to several health issues.

Who is at Risk?

Celiac disease can occur in children of any age once they start consuming foods containing gluten. Children with a family history of celiac disease, those with other autoimmune diseases like Type 1 diabetes, and those with genetic conditions such as Down syndrome are at a higher risk.

What are the Symptoms?

Symptoms of celiac disease in children can vary widely. Common gastrointestinal symptoms include chronic diarrhea, abdominal pain, bloating, and constipation. Non-gastrointestinal symptoms may include delayed growth, weight loss, fatigue, and irritability. Some children may also present with a skin rash known as dermatitis herpetiformis.

How is it Diagnosed?

Diagnosis usually begins with a blood test to check for specific antibodies. If the blood test is positive, a biopsy of the small intestine is often performed to confirm the diagnosis. Genetic testing may also be useful, especially for those with a family history of the disease.

What is the Treatment?

The primary treatment for celiac disease is a strict gluten-free diet. This involves avoiding all foods and products that contain gluten. Adherence to this diet helps in healing the intestinal lining and preventing further complications. Nutritional counseling is often recommended to help families manage the diet effectively.

What are the Complications?

If left untreated, celiac disease can lead to serious complications such as malnutrition, anemia, and osteoporosis. In children, it can also result in delayed puberty and neurological conditions like ADHD and epilepsy.

How to Manage the Condition?

Managing celiac disease involves regular follow-ups with a pediatric gastroenterologist and a dietitian. Parents and caregivers must be vigilant about reading food labels and avoiding cross-contamination in food preparation. Support groups and resources can provide additional assistance and information.

Can Celiac Disease be Prevented?

Currently, there is no known way to prevent celiac disease. However, early diagnosis and treatment can prevent many of the complications associated with the disease. Research is ongoing to better understand the genetic and environmental factors that contribute to its development.

Relevant Publications

Potential of nutraceuticals in celiac disease.

Issue Release: 2024

Celiac disease prevalence in patients with idiopathic inflammatory myopathies, a cross-sectional study.

Issue Release: 2024

Understanding the Genetic Basis of Celiac Disease: A Comprehensive Review.

Issue Release: 2024

Celiac Disease, Gluten Sensitivity, and Diet Management.

Issue Release: 2024

History and familial aggregation of immune-mediated diseases in sarcoidosis: a register-based case-control-family study.

Issue Release: 2024

Human adaptations to diet: Biological and cultural coevolution.

Issue Release: 2024

Down Syndrome and Autoimmune Disease.

Issue Release: 2024

Transcriptomic analysis of intestine following administration of a transglutaminase 2 inhibitor to prevent gluten-induced intestinal damage in celiac disease.

Issue Release: 2024

Managing children and adolescents with type 1 diabetes and coexisting celiac disease: Real-world data from a global survey.

Issue Release: 2024

Clinical presentation of celiac disease in adult patients: current real-life experience.

Issue Release: 2024

A Potential Role for MAGI-1 in the Bi-Directional Relationship Between Major Depressive Disorder and Cardiovascular Disease.

Issue Release: 2024

Evaluation of genetic association between celiac disease and type 1 diabetes.

Issue Release: 2024

Wheat-Related Disorders in Children: A 360-Degree View.

Issue Release: 2024

Vulnerability in Children with Celiac Disease: Findings from a Scoping Review.

Issue Release: 2024

Gluten-Free Diet Adherence Tools for Individuals with Celiac Disease: A Systematic Review and Meta-Analysis of Tools Compared to Laboratory Tests.

Issue Release: 2024

Knowledge Gaps in Gluten-Free Diet Awareness among Patients and Healthcare Professionals: A Call for Enhanced Nutritional Education.

Issue Release: 2024

Taking the Road Less Travelled: A Case Report of Distal Splenic Artery Embolisation via the Pancreaticoduodenal Arcade in Splenic Trauma With Celiac Artery Stenosis.

Issue Release: 2024

Potential Celiac Disease in Children: Health Status on A Long-Term Gluten-Containing Diet.

Issue Release: 2024

Navigating the Labyrinth: When the \"Mesenterium Commune\" Turns Colonoscopy into an Endoscopic Rollercoaster.

Issue Release: 2024

Celiac Disease: The Importance of Studying the Duodenal Mucosa-Associated Microbiota.

Issue Release: 2024

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