The exact cause of NCP remains uncertain, but several factors are believed to contribute to its development. One of the primary suspects is the overgrowth of the yeast Malassezia, which is part of the normal skin flora. The immature immune system of newborns may also play a role, making them more susceptible to this condition. Additionally, maternal hormones that cross the placenta during pregnancy may stimulate the sebaceous glands of the infant, contributing to the development of pustules.