Yes, under certain circumstances, maternal IgG antibodies can cause neonatal disorders. For example, in hemolytic disease of the newborn (HDN), maternal IgG antibodies against fetal red blood cells can cross the placenta and lead to the destruction of these cells, causing anemia in the neonate. Another condition is neonatal alloimmune thrombocytopenia (NAIT), where maternal IgG antibodies target fetal platelets, leading to low platelet counts and an increased risk of bleeding.
