Technological Innovations in Pediatric Epilepsy Diagnosis

Epilepsy is a chronic neurological condition that is truly worldwide, affecting close to 10% of children in the world. This is defined by either recurring seizures or one major seizure, seeing that seizures are momentary disturbances of brain function caused by cerebral electrical events. Epilepsy in children can often be misdiagnosed, mainly because the symptoms are not as conspicuous as in adults, and interpreting tests such as electroencephalograms (EEG). In the last few years, with the help of artificial intelligence and machine learning, approaches to pediatric epilepsy diagnosis have completely changed. By supporting more precise, prompt, and non-ruptive means to detect seizure-related abnormalities in kids, these technologies promise better control or therapeutic approaches to handling these structural abnormalities. 

Machine learning in the diagnostics of pediatric epilepsy can be considered the start of an epoch of value-based medicine. Conventional diagnosis of epilepsy used to involve the identification of epileptic activity on the raw EEG records by clinical specialists. However, this is a very time-consuming technique and not always accurate, especially in some other complicated issues. At the moment, hard work is being done to create smarter algorithms that would improve and simplify the process of analyzing the EEG. For instance, current deep learning strategies have learned to identify patterns in EEG signals that can go unnoticed by human employees. Such patterns mostly help to reveal the nature and place of epilepsy for further treatment. 

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Certainly, the most novel strategy within this context is the employment of deep convolutional neural networks (CNNs). Such networks can be trained with large data samples of EEG records from children and learn to distinguish between normal and pathological brain signals successfully. For instance, by employing a two-dimensional deep convolutional autoencoder model, it has been possible to achieve significant accuracy of ictal and interictal brain state signals in children for classification. This model enjoys particularly high accuracy rates, thus constituting a benefit to clinicians in the diagnosis of epilepsy that does not require invasive methods. 

However, the use of the machine learning algorithm is not restricted to the analysis of electroencephalogram signals. Some of the recent developments in genetic algorithms and other sets of genetic predictors are now being used to predict epileptic seizures, sometimes before they happen. It ensures that the right interventions are offered to children with epilepsy, reducing the overall quality of life they would otherwise lead. The use of features derived from EEG are often used in various predictive models, and these features include those obtained via a genetic algorithm frequency domain search. Such models have been seen to provide promising results for identifying the preictal state in pediatric cases.  

 It also applies to elevating the diagnostic process and including these technologies in reference to clinical practices. For example, automated systems with the help of AI can always superpose EEG signals and notify medical personnel of critical situations in real-time. This capability is well required in the intensive care units, where one has to respond promptly to a developing seizure to avoid serious complications. 

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Also, wearable technology is changing the way epilepsy is monitored in other settings than hospitals. Presently, users are now able to use wearable devices with EEG sensors for the recording of brain activity without the need for invasive processes. There is not only comfort but also general control and assessment of the patient’s status for protracted periods with such devices. The data obtained can be processed with the help of superior computation algorithms to identify possible precursors of a seizure, which can help to take preventive action.  

But, despite the recent technological progress in diagnosing pediatric epilepsy, there are peculiarities. Some of the concerns that are still considered even now include the protection of patients’ information, the lack of sufficient large annotated datasets for training AI models, and models of integrating such technologies into the current healthcare systems. Also, there is the question of what potential outcome of such diagnostic tools could persist or become trusted in the long term. 

Nevertheless, focusing on these difficulties, it is necessary to mention that the development of technology opens new perspectives for pediatric epilepsy diagnosis in the future. With the continued development of these technologies, it will be possible to have better diagnosis and, therefore, better management of such children and a better quality of life for children with epilepsy.

References

  1. Ghazal, T.M., Al Hamadi, H., Umar Nasir, M., Gollapalli, M., Zubair, M., Adnan Khan, M. and Yeob Yeun, C., 2022. Supervised machine learning empowered multifactorial genetic inheritance disorder prediction. Computational Intelligence and Neuroscience2022(1), p.1051388.
  2. Natu, M., Bachute, M., Gite, S., Kotecha, K. and Vidyarthi, A., 2022. [Retracted] Review on Epileptic Seizure Prediction: Machine Learning and Deep Learning Approaches. Computational and Mathematical Methods in Medicine2022(1), p.7751263.
  3. Lekshmy, H.O., Panickar, D. and Harikumar, S., 2022. Comparative analysis of multiple machine learning algorithms for epileptic seizure prediction. In Journal of physics: Conference series (Vol. 2161, No. 1, p. 012055). IOP Publishing.
  4. Nair, P.P., Aghoram, R. and Khilari, M.L., 2021. Applications of artificial intelligence in epilepsy. International Journal of Advanced Medical and Health Research8(2), pp.41-48.
  5. Abdelhameed, A. and Bayoumi, M., 2021. A deep learning approach for automatic seizure detection in children with epilepsy. Frontiers in Computational Neuroscience15, p.650050.
  6. Ilakiyaselvan, N., Khan, A.N. and Shahina, A., 2020. Deep learning approach to detect seizure using reconstructed phase space images. Journal of biomedical research34(3), p.240.
  7. Sharma, P., Hussain, A. and Greenwood, R., 2019. Precision in pediatric epilepsy. F1000Research8.
  8. Kinney-Lang, E., Yoong, M., Hunter, M., Tallur, K.K., Shetty, J., McLellan, A., Chin, R.F. and Escudero, J., 2019. Analysis of EEG networks and their correlation with cognitive impairment in preschool children with epilepsy. Epilepsy & Behavior90, pp.45-56.

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